Smallpox virus particles, or virions, have a characteristic
brick-shape and appear as smooth, rounded rectangles by
electron microscopy, measuring approximately 302-350 nm by
244-270 nm. The smallpox genome is 186 kbp and consists of a
single linear double-stranded DNA molecule with a hairpin loop
at each end. Smallpox virion replication occurs in the cytoplasm.
Smallpox virion replication uses viral-associated deoxyribonucleic
acid (DNA)-dependent ribonucleic acid (RNA)
polymerase. Viral envelopes are made of modified Golgi membranes
containing viral-specific polypeptides. Both enveloped and
nonenveloped virions are infectious. The molecular pathogenesis
of poxviruses is largely based on the studies of monkeypox virus
and mousepox virus.
Contents: Smallpox (Extensive Information)
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