Bioterrorism and Emerging Infection Education
The Current Threat of Smallpox Biological Weapons

Question: What does this image of a young patient's foot reveal?

Answer: This photograph of the left foot of a young smallpox patient shows the typical smallpox lesions located on the foot's plantar surface.


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Since many of the laboratories involved in biological weapons research and development in the former Soviet Union were working with decreased funding in the early 90s, particularly in the areas of staff and support, there evolved concern that bioweapons resources and expertise may spread to other countries. A report from the Washington Center for Strategic and International Studies states that at least ten countries are involved in biological weapon research programs.

The ability of a group to acquire variola and develop it as a biological weapon is limited by the following factors:

  • Specialized skills are required to grow smallpox in effectively large quantities and to adapt it for use as an aerosol-based weapon. It is unlikely that small, technically- limited fanatical or dissident groups would use smallpox as a weapon.
  • The open use of a biological weapon by any nation or political state would undoubtedly illicit severe retaliation.
  • Smallpox virus is not as readily available as other agents of biological terrorism such as anthrax (Bacillus anthracis) or plague (Yersinia pestis).

Evaluation of these and other factors have led bioweapons experts to conclude that well-financed and highly organized subnational groups and politically/state sponsored terrorist groups would be the most likely to use smallpox as a biological weapon.

The following characteristics make smallpox virus an excellent candidate for use as a biological weapon:

  • An aerosol suspension of smallpox virus is quite stable and has a very low infectious dosage. In general, the dissemination of a pathogen by aerosol droplet is the preferred deployment method for biological weapons.
  • There are no large-scale civilian smallpox vaccination requirements at this time. Thus, there is a large susceptible population at risk for smallpox infection. (Note that both military and civilian planners are evaluating the merits of expanding vaccination to much larger populations).
  • Smallpox is a highly contagious disease, spread through droplet inhalation or ingestion.
  • The incubation period in naturally occurring cases (droplet infection) averages 7-14 days. However, this period could be shortened to 3-7 days especially in the cases of aerosol application (in biological weapons).
  • People may be contagious during the late stages of the incubation period, even though they are minimally symptomatic.
  • Depending on the climate, corpses of smallpox victims remain infectious for days to months. Bodies should be cremated, if possible.
  • The duration of disease is long. Coupled with the complex isolation and protection requirements of smallpox treatment, each infected person will require the efforts of several medical and support personnel.

Contents: Smallpox (Extensive Information)             

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